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Brianna: Lost credit card celebrex online purchase âWeâre suggesting the reason the old brain is so vulnerable to Alzheimerâs disease is because of this massive buildup of C1q,â Barres, professor and chair of neurobiology at Stanford, told FoxNews.com. âOne of the things thatâs very interesting about this pattern is that the earliest accumulation of C1q starts in regions of the brain that are well-known to be most vulnerable to neurodegenerative disease â the hippocampus and substantia nigra.â