Kaitlyn: I've got a part-time job detrol la Stop reading right here if you just want to eat your holiday roast in peace. But if the familiar caveats about weight and cholesterol don’t work for you anymore, and you’re looking for a whole new reason for restraint among the rich holiday treats, here it is: High-fat eating wreaks changes in the microbes that inhabit your gut with such dramatic rapidity that even a single day can make a difference.